Without the need of referring to the existence of telomerase as a reason for an unlimited growth of the cancer cell, it maybe said that the production of apoptosis become difficult because of the damage given to mitochondria.

Because of the impairment of cellar oxygen respiration, generation of energy becomes difficult causing successive occurrences of such symptoms as the low body temperature, chilliness of the body and the decline of immunity.

f) The cancer cells are redifferentiated into the normal cells by the differentiation inducing therapy or apoptosis inducing therapy.

The shrunk mitochondria grow bigger and revive and redifferentiate into the cells cancer of oxygen respiration, thus returning to the oxygen respiration cell from anaerobic cell.

Above photographs show the redifferentiation of cells by panax ginsengsasaponin which was reported by Prof. Odazima

The redifferentiation of Morris hepatoma(middle photo) into the normal liver cells is shown(right photo

g) Now, let us think again about the role of HSP. The ability of HSP production within the cell nucleus declines with ages. It is commonly observed that old people tend to have low body temperature. Therefore, assisting the production of HSP by warming, hot-spa therapy, hyperthermia or hot water bathing facilitates smooth carrying of mitochondria protein produced by nucleus into mitochondria and smooth production of ATP.

Furthermore, the smooth production of ATP enables an increase of cyclic AMP production. The cause of decrease of cyclic AMP in cancer patients blood maybe attributable to the shrinkage and diminution of mitochondria.

Now I would like to summarize update HSP research here.

Heat shock protein is not only produced by heat stress but also by ischemic condition. This is coped with a life modulator which was destined 18 billion years ago when protozoa bacteria had a chance to "rendez vous" with red bacteria.

I think the naming of HSP is wrong, but it becomes clear that HSP has a role as a cellular protein life modulator from cradle to graveyard.

Boiled egg was diluted 50 times with buffered saline solution (a) test tube:without HSP of acidophilic bacteria, (b) test tube with HSP) Both test tubes were heated at 70 degree C for 10 minutes. In the (b) test tube there was no aggregation

There is a very important mutual relationship between HSP production and ATP. It is well known that HSP is increased in the ischemic condition. When the cellular energy metabolism is impaired and reduced in ATP production, HSP production is acutely increased.

IT is estimated that this fact made the memory of mitochondria 18 billion years ago at time of cellular, for example, ischemic condition.

Srivastava MD demonstrated that HSP70 and HSP90 in the cytosol of cancer cell, have antigenicity to cancer cell.

As the second fact, when mixture of HSP and peptide complex was added to antigen offering cell, CD8 positive T cell was produced 200〜400 times more than in single peptide.

Om the contrary, when the cell had produced apoptosis, HSP did not appear and immune tolerance was induced to the antigen.

The cyclic AMP is not only a mere differentiation inducing substance but is basically the second messenger of hormone. Normally, a directive from the central nerve system is conveyed to cell through hormone and thereafter it is conveyed to DNA of the nucleus, however, in case of cancer patients, it maybe considered that decline of cyclic AMP in the blood creates a state wherein conveyance of the derective to cell nucleus is hindered resulting in the cancer cells "unsocial reactions".

For a long time, the defective immunosurveillance occurring in cancer patients, had been left unresearched as a mysterious phenomenon. However, our study has proved that it biochemically means "a decline of the concentration of cyclic AMP in the blood" (For details, please refer to Kobayashi T. Enhancement of immunosurveillance in cancer patients.Amer.J.of Acupuncture 15,25-33,1987)

To explain it simply, when an adopted lymphocyte therapy is given to cancer patients with 50 million lymphocytes, the immunity is improved with a 70-80% probability.

Whereas when the lymphocyte therapy is given to advanced cancer patients, the immunity is not much improved with a 33-39% probability. Since it was considered that defective immunosurveillance occurred in the advanced patients, beforehand a fasting therapy was given first and one or two days thereafter, adopted lymphocyte therapy with 50 million lymphocytes was given with a result that the immunity was improved with a 56-71% probability.

The improvement occurs because of the fact that the fasting treatment causes the cyclic AMP in the blood to increase. Through this experiment, the mysterious phenomenon called "defective immunosurveillance" in the field of immunity can be resolved by maintaining biochemically the cyclic AMP concentration in the blood within the normal range.

g) Application of differentiation inducing therapy.

The concentration of cyclic AMP in the blood of cancer patients is abated. Assuming that this is what the defective immunosurveillance means in essence biochemically, then measures to restore the concentration of cyclic AMP in the blood back to stay within the normal range by having the patient undergo a fasting therapy or semi-fasting treatment, should be taken.

As a medical treatment, in this regard, a small quantity of dibutryI cyclic AMP is injected intravenously for a period of 6〜24 hours continuously.

At the same time, if it is made possible to keep the cyclic AMP concentration in the blood at a comparatively high level for a long time, by injecting intravenously aminophylline for a period of 6〜24 hours continuously, which blocks the action of cyclic phosphodiesterase(cPDE) which decomposes cyclic AMP, then the defective immunosurveillance will be improved thus making the defferentiation inducing therapy possible.

The photos below show the differentiation of brain tumor cell (left photo) into normal nerve cell (right photo) as a result of its cultivation adding cyclic AMP.